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The phenomenon was explained by the particular charge distribution in thienylvinyl derivatives preventing the interaction of chromophoric crown ethers with metal ions.
AMG 386 is a peptide-Fc fusion protein that inhibits angiogenesis by preventing the interaction of angiopoietins with the Tie2 receptor.
This mutation was shown to reduce the serum half-life of the scFv-Fc fragment from 10 days to 27 h by preventing the interaction of the intact Fc region with the Brambell receptor (FcRN) responsible for diverting antibodies away from the degradation pathway in cellular lysosomes (Figure 1a). Figure 1 A chimeric intact antibody and single-chain Fv-Fc (scFv-Fc) fragment.
N-WASP is kept in an autoinhibited state through an intramolecular association [13] preventing the interaction of its C-terminus with the Arp2/3 complex [14].
DNA methylation can silence gene expression by preventing the interaction of transcription factors and the RNA polymerase II transcription machinery with target genes [5], [50] [51].
Soluble APNs could act as competitive inhibitors, preventing the interaction of the toxins found in the Xentari™ with the cell surface receptors and contributing to the resistance in Xen-R.
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For example, metyrapone, a compound used clinically in the evaluation of pituitary-adrenocortical function, binds to various cytochromes P-450 in the adrenal, preventing the interactions of steroid substrates with the enzymes and inhibiting steroidogenesis.
This bond formation prevents the interaction of Lys-907 with the phosphate of 5′ppp dsRNA.
The PEG shell prevents the interaction of PLA core with biomolecules, cells, tissues, and can suppress opsonization [11].
Moreover, the dendrimer-shaped motif at the aromatic ring of compound 4b may effectively prevent the interaction of catalytic triad of AChE with substrate.
The moisture gets adsorbed on the active sites on the catalyst surface and prevents the interaction of BC molecules with these sites [26].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com