Because these activating influences converge on membrane interaction, the HDX-MS results could act as a roadmap to design inhibitors that would work by preventing the closed-to-open transition that occurs upon activation and membrane binding.
The relative dead-zone in the adaptation mechanism prevents the closed-loop system against potential instability caused by uncertainties.
Because MDA creates cross-links in apoA-I between H10 (C-terminus) and H5, cross-linking should hinder apoA-I's ability to form discoidal HDL, a key step in reverse cholesterol transport, by locking H10 to H5, preventing the transition from the closed to open form.
Specialist firms, acting as arbitragers, swiftly match the price of the funds to their net asset value, preventing the discounts common with closed-end funds.
At pH below 6.0 6.5, the EF loop moves to a closed position preventing the binding of ligands (Qin et al. 1998).
Post-exposure prophylaxis remains a strategy to consider in preventing the spread of influenza in closed environments and essential personnel populations.
Mixing of the two fluids is prevented by the closed interface valve.
6 7 11 12 Finally, despite the sophistication of the control algorithm and the significant reduction in nocturnal hypoglycaemia, four episodes of severe hypoglycaemia (<3mmol/L) occurred, three of which the authors thought were attributable to the preceding prandial insulin dose and could not be prevented by the closed loop suspending insulin delivery.
Over-expression of ABCISIC ACID-INSENSITIVE3 (ABI3) gene in poplar prevents the formations of closed apical buds upon SD induction, indicating that abscisic acid (ABA) could contribute to the transition to closed bud [ 5, 20].
This simple model, which has the advantage to be computationally inexpensive, could be used to design novel kind of drugs directed against polymerases, namely drugs preventing the open/closed transition from occurring in bacterial or viral DNA-dependent polymerases.
