Sentence examples for preventing its activity from inspiring English sources

The second method is more indirect and relies on initial mislocalization of the protein, preventing its activity and activation of the protein through optochemical translocation to a specific cellular compartment.

Imatinib binds directly to the ATP binding pocket within the kinase, preventing its activity, and thereby causing tumor cell death.

Blogger Aaron Bady distinguishes between the two, saying that "for Assange... a conspiracy is something fairly banal, simply any network of associates who act in concert by hiding their concerted association from outsiders, an authority that proceeds by preventing its activities from being visible enough to provoke counter-reaction".

As expected, inhibitor treatment did not block phosphorylation of p38 MAPK (see also Figures 5b and c) but prevented its activity reducing activation of downstream targets like heat shock protein-27 (data not shown).

Conceptually, an ideal non-substrate-selective inhibitor of p38 would bind p38 and prevent its activity, effectively titrating out the p38.

Furthermore, it has been shown that the metal-free form of MT (apo- MT) may also bind P53 and prevent its activity [ 16– 16].

Similar to the inhibitor IkB, the central canonical Wnt pathway component can bind NF-κB and can prevent its activity (Duan et al, 2007).

These compounds bind to specific positions in domain V of the large ribosomal RNA and prevent its activity in protein folding, without affecting its function in protein synthesis (Tribouillard-Tanvier et al, 2008b).

In order to analyze the importance of TOR complex 2 for growth of tumor cells, we sought to prevent its activity by downregulating Rictor, an essential component of TORC2 [ 9, 10].

In the absence of pathogen, the low amounts of NPR1 that reach the nucleus are degraded by the proteasome, preventing its co-activator activity.

In this model, modified Parp1, through the high negative charge of bound PARs attracts and hosts Dnmt1, thus preventing its catalytic activity.