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We speculate that cell cycle arrest in Insulin+ cells may be induced by Neurog3 (Miyatsuka et al., 2011), thereby preventing dilution of viral transgene-encoded factors.
Persistent transgene expression noted in our study likely results from the known ability of Neurog3 to induce cell cycle exit (Miyatsuka et al., 2011), thereby preventing dilution of transgenes and transgene-encoded factors by cell division.
However, since the reporter gene is integrated in the genomic DNA, cell proliferation will increase rather than decrease signal intensity [ 4], as such preventing dilution of the original labeling signal.
Persistent transgene expression noted in our study likely results from the known ability of Neurog3 to induce cell cycle exit (Miyatsuka et al., 2011), thereby preventing dilution of transgene-encoded factors by cell division.
Similar(56)
That did prevent dilution, but at a high cost.
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As part of its latest "stress tests," Citigroup has asked regulators for permission to buy back a relatively conservative amount of stock, just enough to prevent dilution from routine share issuance, according to The Wall Street Journal.
Whenever possible, debt is preferable to equity because it prevents dilution.
The company isn't planning to make another token sale in the future, representatives told TechCrunch, in order to prevent dilution.
Elizabeth Holmes' use of her own shares to recapitalize our C-2 and C-1 investors and thereby prevent dilution to our other shareholders is consistent with her longstanding, personal commitment to doing the right thing for the Theranos shareholder base.
To prevent dilution of the stock when options were exercised, companies bought an equivalent number of shares on the open market.
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