Sentence examples for prevented its interaction with from inspiring English sources
Indeed, deletion of the C-terminal (RASSF1-interacting) region of MST1 prevented its interaction with CNK1 and despite the fact that both RASSF1A and RASSF1C can interact with CNK1, only RASSF1A is able to augment CNK-induced apoptosis [157].
The alterations of three highly conserved residues in LATS1/2-A77/76P-I81/80T-L85/84P prevented its interaction with Merlin/NF2, membrane localization and activation (Yin et al., 2013).
Substitution mutation K30A in the TPR domain of CHIP prevented its interaction with Hsp70/90.
The lead compound ICG-001 that was selectively bound to CBP and prevented its interaction with β-catenin was identified using a cell-based reporter screen.
Furthermore, an internal deletion of the UAP56-binding motif within UIF prevented its interaction with GST-UAP56 in pull-down assays.
Moreover, the deletion of the 49 C-terminal residues of receptor, which prevented its interaction with mTOR, strongly reduced its ability to activate mTOR, without affecting its coupling to Gαs.
Dkk1 is a known Wnt/β-catenin pathway inhibitor: it binds to Lrp5/6, preventing its interaction with the Wnt protein and disrupting the Wnt-induced Frizzled-Lrp6 complex formation necessary for signal transduction [3], [4], [5].
A more surprising claim in this study is that Rab6A can also bind to the KIF1C motor domain, prevent its interaction with microtubules and convert it into an inter-membrane tether.
It binds to TNF-α and prevents its interaction with cell surface receptors, thus interfering with the inflammatory cascade.
TGF-β is a potent cytokine and growth factor whose biological activity is primarily regulated post-translationally [ 30], because it is transcribed and translated as a small latent complex composed not only of active TGF-β, but also of a latency-associated peptide (LAP) to which it is noncovalently bound and which prevents its interaction with its specific receptors on the target cell surface.
This localization maintains γ-catenin stability by preventing its interaction with Ub machinery (Sadot et al., 2000).
