Sentence examples for prevented from interacting from inspiring English sources

In the autoinhibited state its tandem SH3 (Src homology 3) domains are engaged in an intramolecular interaction with a region rich in basic residues (polybasic region, also referred to as autoinhibitory region AIR) and hence are prevented from interacting with p22phox [23], [23](Figure 1).

We found here that several agents previously reported to inhibit anandamide cellular uptake lose their efficacy when anandamide is prevented from interacting directly with plasma membrane proteins, thus arguing in favor of the specificity of such agents for the putative "anandamide transporter", and of the existence of such mechanism.

When the number of binding sites (pY sites) is limited (as it would occur at low EGF doses), low-affinity binders (as Cbl hypothetically might be) would be prevented from interacting with the EGFR.

GDIs also sequester Rho GTPases as soluble cytosolic complexes in which the C-terminal membrane-targeting lipid moiety of the GTPase is prevented from interacting with membranes [ 25, 26].

Interestingly, the REA protein can be prevented from interacting with, and thus inhibiting, the ER by sequestration with prothymosin α (PTα) and it may be no coincidence that PTα expression is high in some breast tumours.

We found that removal of the GH3 domain prevented Reaper from interacting with MFN2, which initially suggested simply that mitochondrial localization was critical for interaction.

It could be inferred that, the reduction of total acid sites due to the coke covered on the active sites, prevented reactants from interacting with active sites.

Polystyrene nanospheres coated with cationic poly vinylamine) and cholestyramine, which is clinically used as a cholesterol-lowering agent, dramatically prevented DX-9065 from interacting with chenodeoxycholic acid in vitro.

To determine if MDM2 is involved in pRB stability in siLmna cells, we prevented pRB from interacting with MDM2 in siLmna cells.

When the mice were given antibodies that prevented transthyretin from interacting with the β-amyloid protein, the mice showed typical brain cell death.

We found that mutations in the basic and conserved patches (Mut-1 and Mut-2) prevented PatL1 from interacting with DCP2, EDC4 and the LSm1 7 ring as efficiently as deleting the Mid and Pat-C domains.