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These data establish that autophagy inhibition is achievable with HCQ, but dose-limiting toxicity prevented escalation to higher doses of HCQ.
Their overlapping toxicity profiles prevented escalation of topotecan, in combination with IF, to a dose near the single-agent MTD of 1.5 mg m−2 day−1 for 5 consecutive days.
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The measures used also did not differentiate between different levels or types of prevention services such as primary (preventing initiation) or secondary prevention (preventing escalation).
Instead, the United States relied on covert coercion to prevent escalation.
Accidental gas releases are detected by allocating sensors in optimal places to prevent escalation of the incident.
The best way to prevent escalation, he added, is to notify the police at the first sign of abusive behavior.
A top Coptic leader, Father Saleeb Metta Sawiris, said Wednesday that church officials were seeking to defuse the conflict and prevent escalation.
Collectively, these reforms can help restructure the National Flood Insurance Program to prevent escalation of debts, reduce taxpayer burden, and most importantly increase the safety of millions of vulnerable homeowners.
Collectively, these reforms can help restructure the NFIP to prevent escalation of debts, reduce taxpayer burden, and most importantly increase the safety of millions of vulnerable homeowners.
Like a good parent, the state should set clear rules and boundaries from the start, dealing with transgression swiftly and surely to prevent escalation.
"If we are to prevent escalation here, Syria must restrain Hezbollah," said Raanan Gissin, the spokesman for Ariel Sharon, the Israeli prime minister.
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CEO of Professional Science Editing for Scientists @ prosciediting.com