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Up to 3 years after TBI, however, patients could have post-traumatic headache that interfered with or prevented activities of daily living according to our results.
Additionally, moderate-to-severe headache (NRS ≥ 4) might have more clinical relevance compared to mild headache (NRS ≤ 3), because mild headache was described as interfering little with activities of daily living, while moderate-to-severe headache interfered with or prevented activities of daily living.
We focused on moderate-to-severe PTH, which might have more clinical relevance, because mild PTH (NRS 1 to 3) was described as interfering little with activities of daily living, while moderate-to-severe PTH (NRS 4 to 10) interfered with or prevented activities of daily living.
Severity was graded as either absent/none (Grade 0), mild (Grade 1, easily tolerated), moderate (Grade 2, interfered with activities of daily living), or severe (Grade 3, prevented activities of daily living).
Adverse events were graded as either mild (easily tolerated), moderate (interfered with activities of daily living), or severe (prevented activities of daily living), and assigned causality relative to the study vaccine.
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