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Inhibiting p38 MAPK prevented activation of the transcription factor ATF-2 and CREB, and significantly reduced the LPS-induced up-regulation of co-stimulatory molecules [26].
Dipyridamole and DIDS also prevented activation of the conductance.
Importantly, Mohamed et al. reported that glibenclamide prevented activation of the Nalp3 inflammasomes [ 13].
Finally, the use of lactacystin, another proteasome inhibitor, also prevented activation of the IFN-β promoter.
Downregulation of IFN-beta prevented activation of the IFN-beta receptor and subsequent STAT1 phosphorylation and ISRE activation [ 36].
The ORAI1 inhibitors also prevented activation of the necrotic cell death pathway in mouse and human pancreatic acinar cells.
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Since it has been reported previously that inhibition of proteasome activity prevents activation of the Nalp1b inflammasome [38], [39], we sought to determine whether celastrol inhibits processing of IL-18 by the Nalp1b inflammasome.
During geminivirus infection, NSP interacts with the kinase domain of NIKs to inhibit their kinase activity, preventing activation of the defense response.
Pacifastin is an efficient inhibitor of ppA (prophenoloxidase-activating enzyme) and this inhibitor prevents activation of the proPO system.
Identification of the underlying mechanisms could enable us to design rational therapies that prevent activation of the recipient's innate immune response.
The moment controlling the flap activation depends mainly on the net soil pressure on the front or back face of the flap, and this prevents activation of the flap while the anchor is rotating significantly.
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