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Bravo says what employers may overlook is that they win, too, when they prevent turnover and help a single mom like Ashley keep her job.
Health promotion programs aimed at healthcare workers are suggested to reduce job stress, prevent burnout, improve health, and probably prevent turnover [ 8, 9].
Such a compound would stabilize the bound conformation and prevent turnover of a specific substrate, enabling selective targeting of one pathway controlled by GSK-3.
First, to identify the binding site for a substrate water molecule on the C-cluster of MtCODH/ACS, we grew crystals in the complete absence of CO to prevent turnover.
Consistent with this hypothesis, the appearance of heterochromatic marks at sites of neocentromere formation (Amor et al. 2004) would reflect the formation of compacted structures that prevent turnover events causing replacement of cenH3 nucleosomes.
Loss of PINK1 was sufficient to prevent turnover of MFN2 (which has been shown to be dependent on the PINK1/Parkin pathway in response to mitochondrial depolarization [ 16]), but did not alter mitophagy in response to DFP (Fig 4C E).
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And that was running the ball to prevent turnovers and sacks and producing low-scoring games that play to the strength of the Giants' mature defense.
In particular, a calpain-insensitive mutant of talin prevented turnover of adhesions in fibroblasts [7].
We confirm that zebularine exerts its demethylation activity by stabilizing the binding of DNMTs to DNA, hindering the methylation and decreasing the dissociation, thereby trapping the enzyme and preventing turnover even at other sites.
Thus, we might think of the compaction and absence of genes in centric heterochromatin as adaptations for preventing turnover that would otherwise evict cenH3 nucleosomes.
We conclude that mAb KIM127 prevents turnover of LFA-1/ICAM-1 athroughnts through its ability to stabilize LFA-1 adhesions at the leading edge.
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