Sentence examples for prevent trail from inspiring English sources

Furthermore, the fact that nystatin, a cholesterol-sequestering agent, can partially prevent TRAIL receptor localization into lipid microdomains and consequently reduce TRAIL-induced apoptosis in NSCLC cells appears in agreement with our data indicating a significant reduction of TRAIL-induced apoptosis by using the raft disruptor MBC.

Decoy receptors lack a functional death domain, and consequently they do not induce apoptosis and can prevent TRAIL binding to death receptors.

Data from Fig.  1b shows an expression of TRAIL in Ad.TRAIL infected 293 cells in the absence/presence of caspase inhibitor z-VAD-fmk, which was added to prevent TRAIL-induced apoptosis.

The root section failure can be reduced by (1) adjusting the thickness of the structure or increasing the number of plies in the composites laminate stacking and by (2) adjusting the bonding technique to prevent trailing-edge failure.

Furthermore, siRNA-mediated downregulation of Bim was found to prevent TRAIL-induced LMP [ 50].

Although knockdown of CHOP does not prevent TRAIL-induced apoptosis, it abrogates the potentiation of TRAIL-induced apoptosis by salubrinal.

Finally, overexpression of inhibitor of apoptosis proteins (IAP) can prevent TRAIL-induced apoptosis through inhibition of effector caspases (caspase-3, -6 and -7) (Aggarwal et al, 2004).

Although TRAIL may induce reactive oxygen species (ROS) accumulation and ROS is one of the inducers of eIF2 α phosphorylation, treatment with antioxidant does not prevent TRAIL-induced eIF2 α phosphorylation (data not shown).

Taken together, our data indicate that inactivation of functional PTEN and the consequent activation of the Akt pathway prevents TRAIL-induced apoptosis, leading to TRAIL resistance.

Of particular interest, macrophages and IL-1β prevented TRAIL-induced cleavage of β-catenin, but only in cells with intact NF-κB/AKT/Wnt signaling (Fig. 5B).

THP1 macrophages and IL-1β precluded TRAIL-induced collapse of the mitochondrial membrane potential (MMP) (Fig. 2B) and prevented TRAIL-induced activation of caspase-8 and caspase-9 (Fig. 2C).