Thus, it is important to minimize or prevent therapy-related complications.
The recent guidelines recommend to prevent therapy-associated WL during therapy (Arends et al, 2006).
For postmenopausal patients, the Z-FAST and ZO-FAST trials investigated the efficacy of immediate versus delayed zoledronate (4 mg intravenously every 6 months for 5 years) to prevent therapy-related bone loss in patients with hormone receptor-positive stage I III BC, who were receiving endocrine therapy (letrozole) [ 45].
Taking into account the conclusions of these studies, it was considered that the best nutritional strategy for the patients in this study was to use dietetic counseling and oral nutritional supplementation to increase dietary intake and prevent therapy-associated weight loss.
The stroma, the barrier surrounding the pancreatic tumor, is a resistant shield preventing therapy from reaching the tumor effectively.
Third, since progressive β-cell failure is to be prevented, therapy must be started early in the natural history of type 2 diabetes.
Previous antimetabolite therapy should not prevent infliximab therapy since in ACT-1 and ACT-2 such patients were clearly responding.
Defined manipulation or regulation of these processes may thus help to either enhance tumor therapy or prevent tumor therapy-induced tissue toxicity.
However, the very low engraftment efficiency and survival of implanted cells prevent cell therapy from turning into a clinical reality.
Occasionally rightly so, but often do the methodological design prevent manual therapy studies from reaching what is considered gold standard in pharmacological RCTs.
Unfortunately, he added, there are hurdles that still prevent phage therapy from being a silver bullet, even in a lab.
