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Because there are no complement regulatory proteins – which usually inhibit complement activation on eukaryotic cells – present on the cartilage surface and because the bound IgGs are able to bind C3b and prevent the binding of the complement regulatory plasma proteins factor I and factor H, formation of the C3 convertase is possible.
This shows that when they are premixed the functionalized GNPs bind to EC-178 and prevent the binding of the latter to DU-145, thereby increasing the cell viability.
PP-4 binds to TRAF6 to prevent the binding of TRAF6 to IRAK-2 and so provides an additional negative feedback loop to stop OSM signaling.
Under altered redox conditions in the PCC, rbcL may bind to rbcL, and prevent the binding of stablizing RBPs (like MRL1 and RLSB) leading to decreased rbcL transcripts.
As the binding of ubiquitin activates USPs, it is desirable to identify compounds that bind to the catalytic domains and prevent the binding of ubiquitin.
The activity of histamine can be blocked by various chemical drugs called antihistamines, which prevent the binding of histamine to these receptors.
Each of those gels was designed to prevent the binding of HIV to cells in the vagina.
In a competition with cadmium II) or mercury II), zinc II) cannot prevent the binding of toxic metal ions by the thiolate donor groups of the ligand.
A major target of inhibitor design is to prevent the binding of gp41 C-terminal region to the trimeric coiled coil of fusion-active N-terminal region.
The functionality maps are also used to design a library of disubstituted indoles that might prevent the binding of the protein substrates.
Some goitrogens (e.g., thiocyanates) reduce or inhibit the uptake of iodide; others (e.g., thiourea, thiouracil) inhibit the peroxidase system and thus prevent the binding of iodine to thyroglobulin (a large protein that is cleaved to form the thyroid hormones and that is stored within the follicles of the thyroid gland).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com