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For cases where mAbs are intended to engage cell surface receptors and prevent receptor-ligand interactions (i.e., antagonists), it may be desirable to reduce or eliminate effector function for example to prevent target cell death or unwanted cytokine secretion.
Following two factors are important to understand the net erosion formation: (i) ratio of the 1st ionization length of sputtered W atom to the Larmor gyro radius of W+ ion, (ii) balance between the friction force and the thermal force exerted on W ions. DEMO divertor design should take into account these factors to prevent target erosion.
Proof-of-principle that PA substitution need not prevent target recognition was obtained from studies using PPIP5K2.
An important function of the small heat-shock proteins (sHSPs) is to prevent target (also called substrate or client) proteins from aggregating under conditions that promote protein unfolding.
(B) Intermediate- or short-acting drugs are recommended to lower the blood pressure as soon as possible to prevent target organ damage.
Characterization has confirmed that the vector contains an attenuated catalytic domain to prevent target cell death, and in doing so a therapeutic range for the vector was determined.
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Understanding genetic contributions to blood pressure may provide insight into the mechanisms underlying ethnic disparities in cardiovascular disease, and findings may assist in more personalized and targeted treatments to prevent target-organ damage and its associated morbidity and mortality.
The foundation created the do-not-track feature to prevent targeted advertising.
Although there is nothing to prevent users with blocked accounts from creating new ones, Microsoft has said it might also enforce "console bans" designed to permanently prevent targeted machines accessing its network.
iOS 6 also comes with a "Limit ad tracking" user control in the general settings menu to allow users the option to prevent targeted advertising.
Even with slower clearance, the 15-hr half-life of internalization sequesters enough antibody to prevent targeting of all antigens.
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