Palafox says, "We clearly know early intervention can halt the progression of the illness and prevent subsequent brain damage..
As one type of anti-inflammatory cytokines, IL-10 was found to prevent subsequent tissue damage by inhibiting activation of phagocytes, including neutrophils and monocytes [ 74].
The product of SOD, H2O2 is usually degraded by peroxidases to prevent subsequent cellular damage; however, H2O2 may also function as a signaling molecule.
Early diagnosis of joint inflammation and early institution of immunosuppressive drug treatment -- targeted at reducing synovial inflammation -- is now being advocated in order to prevent subsequent joint damage and disability [ 11].
This is consistent with previous observations of the immune cell complement in regressing murine mammary gland [ 28] and supports the hypothesis that neutrophil numbers are suppressed in involuting tissues in order to prevent subsequent tissue damage [ 28, 29].
It was proposed that one role of this protein in involuting mammary gland and uterus was to eliminate infiltrating neutrophils by inducing apoptosis [ 62] and therefore to prevent subsequent tissue damage [ 63].
From the viewpoint of an early renal support strategy, the goal of early RRT is to maintain solute clearance and fluid balance to prevent subsequent multiorgan damage, while waiting for the recovery of renal function.
Animal models have suggested that lowering serum [Na+] after overcorrection can prevent subsequent brain damage from occurring [ 79, 80], and this would be consistent with the occurrence of a delayed immunological demyelination as a result of complement influx into the brain following a sustained blood brain barrier disruption [ 75].
From the view point of an early renal support strategy, the goal of early RRT is to maintain solute clearance and fluid balance to prevent subsequent multi-organ damage, while waiting for the recovery of renal function [ 8].
This way TRF2 may directly stabilize the t-loop to sequester the 3' end from damage signaling and prevent subsequent recombination steps that would result in loss of telomeric DNA from chromosomes.
