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In the absence of klp2p, MT overlaps that form away from the medial region of the bundle are not relocated to the center [23], [53], which could prevent stabilization of the daughter microtubule.
This is opposite to the experimental finding that brief dominance will prevent stabilization, and longer dominance is required for a percept to recur [Figure 2b in the present work, Figure 3c in 3].
Consistent with this model, it is known that antagonism of AMPARs, which would prevent stabilization of new contacts, blocks the antidepressant actions of ketamine (Maeng et al., 2008; Koike et al., 2011).
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As shown in Fig. 6B, treatment of cells with LY294002 indeed precluded macrophages/IL-1β/TNFα-mediated inactivation of GSK3β, and completely prevented stabilization of Snail by macrophages, TNFα and IL-1β.
RAGE knockdown also prevented stabilization of the Beclin-1/VPS34 complex, further limiting the autophagic response.
Fidelity of chromosome segregation is ensured by a tension-dependent error correction system that prevents stabilization of incorrect chromosome microtubule attachments.
These results demonstrate that uPAR is probably a client protein of the HSP70/MRJ chaperone complex and knockdown of HSP70/MRJ prevents stabilization of client protein and leads to the degradation of the client protein by the proteasome.
Drugs designed to prevent thrombus stabilization rather than inhibition of its formation are currently not available.
Thus, MinC might prevent the stabilization of FtsZ polymers by ZapA.
Our analysis of finite populations exemplified how genetic drift can sometime prevent the stabilization of allele-frequency oscillations, endangering the long term persistence of the HEG.
Concomitantly, Aurora B activity is required to prevent premature stabilization of kinetochore microtubule attachments, thus protecting from errors (model 2, Figure 1B).
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