Sentence examples for prevent repressive from inspiring English sources

At some insulators, we discovered that CBP functions to prevent repressive H3K27 methylation from spreading into active genes.

When bound to insulator sequences (CTCF-binding sites), CTCF can prevent repressive heterochromatin from spreading into neighboring regions [ 11, 12].

At a subset of these, CBP may regulate insulating activity, measured as the ability to prevent repressive H3K27 methylation from spreading into adjacent chromatin.

It has been proposed that MES-4 indirectly affects X chromatin structure by preventing repressive factors from accessing autosomal chromatin, thereby focusing their action on the X chromosome [ 17].

Thus, the E1-functions are replacing the selection marker and prevent the repressive effect of the surrounding heterochromatin.

In schizophrenia, it was shown most recently that histone deacetylase (HDAC) inhibitors prevented the repressive histone modifications induced at the metabotropic glutamate 2 receptor promotor by atypical antipsychotics and augmented their therapeutic effects [ 63].

In this instance, it was suggested that acetylation functions to prevent the transcriptionally repressive modification of sumoylation (81).

We speculate that the intragenic enhancer may be marked in early embryogenesis by pioneer factors that maintain an open, poised chromatin status [ 22] and prevent assembly of repressive factors associated with the spreading of Kcnq1ot1 [ 4, 5].

In the rest of the world, regulation and repressive taxation prevent the emergence of vibrant financial markets.

These observations in toto suggest that a heritable epigenetic template generated by transcription-dependent H3K36 methylation in adult germ cells, which can persist in gamete chromatin and is maintained in the zygote by MES-4 activity, helps prevent encroachment of a repressive chromatin by PRC2-mediated H3K27 methylation in the offspring.

We have identified highly specific inhibitors of HUWE1 and found that inhibition of HUWE1 is a feasible approach to inhibit MYC function in a tumor cell-specific manner, since HUWE1 is required to prevent assembly of a repressive complex of MYC with MIZ1 on MYC-activated target genes.