Here, we propose that β-sheet edge in natively folded amyloid oligomers not only protects proteins from undergoing β aggregation but also prevents interacting molecules from undergoing β aggregation.
These competitive molecules can sequester miRNAs to prevent them interacting with their natural targets to play critical roles in various biological and pathological processes.
It was nothing to do with our personalities, but being two adults travelling together prevented me interacting with the local people as I like to".
In the autoinhibited state its tandem SH3 (Src homology 3) domains are engaged in an intramolecular interaction with a region rich in basic residues (polybasic region, also referred to as autoinhibitory region AIR) and hence are prevented from interacting with p22phox [23], [23](Figure 1).
These miRNA-binding RNAs or 'miRNA sponges' are competitive regulators that sequester miRNAs which prevents them interacting with their intended targets (8 10).
GDIs also sequester Rho GTPases as soluble cytosolic complexes in which the C-terminal membrane-targeting lipid moiety of the GTPase is prevented from interacting with membranes [ 25, 26].
Interestingly, the REA protein can be prevented from interacting with, and thus inhibiting, the ER by sequestration with prothymosin α (PTα) and it may be no coincidence that PTα expression is high in some breast tumours.
When the number of binding sites (pY sites) is limited (as it would occur at low EGF doses), low-affinity binders (as Cbl hypothetically might be) would be prevented from interacting with the EGFR.
TolA did not prevent PBP1B from interacting with CpoB; thus, interaction with TolA may instead alter the conformation of CpoB in a manner that both prevents it from interacting with LpoB and, concurrently, from modulating PBP1B TPase activation by LpoB.
These compounds mimic the interactions between p53 and MDM2 to prevent them from interacting with each other, which results in the activation of p53.
