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Despite its importance, few structural models of the Purkinje network have been developed, primarily because current physical limitations prevent examination of the intact Purkinje network.
We have failed to determine the direct effects of TSA on Th cell differentiation in vitro because TSA suppressed naïve CD4+ T cell proliferation so strongly as to prevent examination of the functional differentiation.
Limitations include the facts that the sample size and duration of follow-up prevent examination of specific cancers, and that for 12% of the 851 cancer cases, date of death had to be substituted for diagnosis date.
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In addition to the above findings, the most important reason behind the inadequacies in the quality control procedures was identified as the various practicality constraints which had prevented examination boards from adequately enforcing their quality control procedures.
All F2 progeny homozygous for the dcl3 mutation were transcriptionally silenced for GUS, whether they carried one or two copies of the GUS transgene (Mlotshwa and Vance, manuscript in preparation), preventing examination of the role of DCL3 in sense transgene-induced silencing in this system.
This prevents examination of the relation between these outcomes over time and also limits genuine assessment of new onsets.
Historical data representing epoch one are available only in aggregate form, preventing examination of temporal trends or confounding factors.
In the current analysis, the low number of LBW cases prevented examination of the risk associated with prenatal PAH exposure.
Because small numbers prevented examination by most individual ICD-9 codes, we grouped sites by organ system.
Despite these advantages, these mice present with a very invasive phenotype, preventing examination of early transformation events [ 50].
Another limitation of the study was that catecholestrogen levels were not measured, therefore preventing examination of individual catecholestrogen levels along with levels of oxidative stress and breast density.
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