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Care must be taken to prevent disseminated intravascular coagulation (DIC), complicating the treatment of APL when the promyelocytes release the contents of their granules into the peripheral circulation.
A tendency toward fibrinolysis is a compensatory response to prevent disseminated intravascular coagulation (DIC) which can result from shock.
While the value of BCG vaccination in early childhood to prevent disseminated disease is widely accepted the value of BCG vaccination in adult population particularly for pulmonary disease has been challenged in high burden countries [60].
Vaccination of adults to prevent disseminated coccidioidomycosis would provide a modest health benefit similar in magnitude to other vaccines but would increase net expenditures.
From a clinical perspective, this suggests that hemodynamic resuscitation should not only be targeted to increase oxygen delivery during the first hours of sepsis but to normalize microvascular blood flow velocity as an option to prevent disseminated leukocyte accumulation throughout the course of the syndrome.
Thus, GD2-retargeted T cells cannot completely prevent disseminated tumour growth in this systemic disease model, but are active to delay and reduce pulmonary disease manifestations.
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BCG vaccination prevents disseminated TB in young children, but fails to prevent adult pulmonary TB which represents the bulk of the global disease burden.
In addition, rhAPC prevented disseminated intravascular coagulation.
Since the government removed most of those associated with the anti-Erdoğan Gulenist movement within the communications-related departments of the state back in December 2013, as a measure to prevent them disseminating information against the government, the plotters were unable to block the social media, especially Twitter and Facebook, for quite a long time.
This has been addressed by assessing and evaluating the policies and procedures in place for preventing dissemination bias by the main parties involved in approving, funding, conducting, publishing, disseminating and assessing clinical research.
Our observations point out to the importance of reducing tumor angiogenesis and inducing an efficient immune response at early stages of primary tumor establishment in order to prevent and/or eradicate disseminated 4T1 metastasis before surgical intervention.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com