Sentence examples for prevent cell cycle progression from inspiring English sources

This was made possible since the expression of the chimeric proteins did not prevent cell cycle progression.

To prevent cell cycle progression into anaphase we retained the cells in the HU block.

One function of ZBTB16 is to prevent cell cycle progression [ 36] and suppress solid tumorigenesis [ 37].

These two pathways converge to maintain an efficient inhibition of CDK1 and hence prevent cell cycle progression.

Replication forks collide with the inhibited topoisomerase complex creating DNA breaks that rapidly activate Chk1 and prevent cell cycle progression.

Therefore, inhibiting the transition of other remaining checkpoints should prevent cell cycle progression and reduce DNA damage repair time, resulting in more tumor cells killed by radiotherapy [ 35].

Disorganized tubulin polymerization prevents cell cycle progression.

Chk1 and Chk2 negatively regulate the Cdc25 family of phosphatases thereby preventing cell cycle progression as well as directly modulating repair proteins resulting in increased lesion repair.

Specifically, p21 prevents cell cycle progression from G1 to S phase by inactivating the Cdk2-cyclin E complexes, that, in turn, inhibit the tumor suppressor protein retinoblastoma (pRb) required for entering S-phase[23].

Perhaps, up-regulation of male-specific miRNA, including the let-7 family, may play a role in preventing cell cycle progression despite high levels of expression of miR-17-92 miR-17-92 miR-17-92

Although diploid ctf4Δ mutants appear to be competent for spontaneous recombinational repair [40], (Fig. 3A) damage-induced recombination may be compromised [54] suggesting that diploid ctf4Δ mutants may have persistent DOX-induced DNA damage that elicits a prolonged G1 arrest signal that prevents cell cycle progression similar to that seen for rad51Δ cells at high DOX doses (Fig. 1C).