The most prevalent pattern of gene expression changes was an increased expression level in the infarct tissue, compared to both control and remote groups.
This confirms previous reports in this (13) and other (15) FRDA models, and suggests that frataxin deficiency induces a prevalent downregulation of gene expression.
Translational control is a prevalent mode of gene expression regulation that chiefly contributes to the poor correlation often observed between the transcriptome and the proteome ([ 1, 2] and references therein).
Analysis of GO categories (EC; Additional file 5), revealed that the most prevalent changes in gene expression occurred in enzymes involved in metabolic processes associated to aromatic compounds (Table 1).
Our analyses also revealed extensive networks of intercellular communication and suggested prevalent sexual dimorphism in gene expression in the heart.
A prevalent means of regulating gene expression in bacteria is by riboswitches found within mRNA leader sequences.
In addition to their prevalent use for analyzing gene expression, DNA microarrays are an efficient tool for biological, medical, and industrial applications because of their ability to assess the presence or absence of biological agents, the targets, in a sample.
Intensive research over the last several years has led to the appreciation that these tiny RNAs act via a highly prevalent, and generally conserved, gene expression regulatory mechanism that impacts development, homeostasis and disease.
With the advent of next-generation sequencing (NGS) technology and its meteoric growth [ 5, 6], RNA-Seq is slowly becoming prevalent in high-throughput gene expression studies [ 7].
While the low-molecular-weight PCBs elicited ER activation and ER-dependent gene expression, prevalent and more persistent high-molecular-weight PCB congeners were antiestrogenic (Table 1, Figures 3 and 4).
