Sentence examples for prevalent alteration from inspiring English sources

In paediatric PTC (spontaneous and radio-induced), RET/PTC rearrangements are the most prevalent alteration (60 80%), while BRAF point mutation is only observed in about 4% of the cases (Nikiforov, 2002; Xing, 2005).

Recently, an innovative approach based on inhibitors of the mutated BRAF gene (which represents the most prevalent alteration in melanoma patients) appears very promising from the clinical point of view.

Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in ∼20% of samples.

Missense mutations are the most prevalent alterations (75%) located mainly within the DNA binding domain.

In all muscle biopsies the prevalent alterations were myopathic atrophy and hypertrophy, increased number of internalized myonuclei, necrosis and regeneration, and fibro-fatty substitution.

Microarray analysis identified among the most prevalent alterations in cervical tumors and cell lines the amplification of the RBP1- Retinoletinol binding protein 1 and 2, 58.8%) and Tp63 (52.9% of the samples) genes, located at 3q21-q22 and 3q27-q29, respectively.

C > T substitution is the most prevalent base alteration in most cancers and even more prominent among harmful substitutions leading to amino acid alterations (Additional file 2: Figure. S1).

All mutations identified in the prevalence set are shown in Additional file 12. Unsurprisingly, the most prevalent genetic alteration detected in this cohort comprised a broad spectrum of TP53 mutations (38.3 %).

Other than stiffness, another prevalent vascular alteration is calcification in the aging population [ 22].

The c.5266dupC mutation is the most prevalent BRCA1 alteration in Europe and a geographic distribution of this mutation is consistent with its Baltic origin [ 19].

Changes due to MV could not be dissected from the already prevalent severe alteration in the lungs due to pneumonia (see Additional file 5).