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For detection/exclusion of infections at a pre-specified prevalence threshold and confidence level (e.g. 99%), the required sample is rather small, but the information obtained from the data is limited.
The population size simulated was N = 100,000 and therefore the prevalence threshold below which scrapie was considered eradicated was 0.001%.
A larger population with the same initial prevalence at the onset of infection would result in identical predictions for PrP haplotype frequencies and scrapie prevalence, but would also impose a lower prevalence threshold corresponding to one infected individual.
Investigation of the impact of using the estimated mf prevalence threshold for filarial disease as an intervention endpoint in MDA programmes was carried out by simulation using EPIFIL, a deterministic model for LF transmission [5], [24], [25].
The prevalence, threshold and significance of TnI elevation remain uncertain.
Predicted prevalence was compared with observed prevalence, dichotomized, according to a 50% observed prevalence threshold.
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The classification into high, moderate, or low yaws prevalence corresponded to World Health Organization prevalence thresholds for identifying appropriate operational treatment strategies.
The classifications of "high", "moderate", and "low" correspond to the WHO prevalence thresholds for identifying appropriate public health interventions and operational treatment strategies [2].
This is further supported by the results from the culicine model which show that including only the mating function will result in much lower worm breakpoint prevalence thresholds (Fig. 2B).
Full data were available for nine of 17 countries with prevalence thresholds for HIV/AIDS above 5% or with more than one million patients.
Finally, the impact of using a TAS decision rule to classify districts according to prevalence thresholds was explored in this analysis.
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