Exact(7)
A quantitative real-time LCR protocol was developed to assess the prevalence of mutant (V136) polymorphism in extracts from DNA pools (genomic or plasmid) and natural extracts from individual ovine milk samples.
This suggests that the high prevalence of mutant genotype may increase the susceptibility to oxidative stress associated diseases.
Also, it was used to compare the prevalence of mutant alleles and heteroplasmy between normal and tumour samples.
This potential correlation is exemplified by the prevalence of mutant TP53 in "chromothriptic" Li-Fraumeni syndrome associated Sonic-Hedgehog medulloblastomas [ 23].
In endemic settings, this fitness cost manifests as a reduced prevalence of mutant pfcrt or pfmdr1 following the release of selective drug pressure [ 32– 32].
The objective was to find out the prevalence of mutant allele frequency of the evaluated catalase (-21 A/T) gene polymorphism in healthy individuals among the south Indian population.
For example, the prevalence of mutant alleles of pfcrt 76T decreased from 64.5% in 2002 to 16% in 2004 and that of mutant pfmdr1 86Y alleles decreased from 46.6%to2.7%7% two and half year after CQ withdrawal in coastal Tanzania [ 38].
Similar(1)
As such, a locus was considered to be beneficial or deleterious in aminoglycosides if i) the prevalence of mutants where the locus was disrupted changed significantly during the enrichments for at least two of the four drugs and ii) the z-scores for the locus for all four drugs had the same sign.
Related(1)
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