These results confirm the high prevalence of evolutionary modifications within our set of predicted motifs and suggest that regulatory element modifications can be detected using statistical methods based upon different underlying assumptions.
The prevalence of dose modifications owing to DRAEs (Supplementary Figure 1) was generally consistent with the prevalence data for DRAEs.
These results are somewhat obscured by the prevalence of RNA modifications within these sequences (Supplementary Figure S3).
This simplifies the problem to a basic occupancy analysis which is insensitive to changes in the affinity of TF binding or in the prevalence of histone modifications.
In the oldest patients, the prevalence of dose modifications owing to DRAEs tended to be higher than in younger patients; however, the relatively small number of patients in the oldest group after month 12 precludes meaningful conclusions.
I found that the proliferative neuroepithelium during the stage of mainly symmetric expansive divisions is characterised by the prevalence of H4R3me2s modification and almost no detectable H4R3me2a modification.
In our study, the prevalence of cytological modification was 3%.
The prevalence of cytological modification was 3% of ASCUS or more severe, in the centres using the Pap test as primary screening.
Despite the prevalence of body modification, especially among adolescents [ 1, 5, 8] and the associated health risks [ 1, 9- 12], these practices are currently not sufficiently regulated [ 13- 17].
We note that the difference of skewness is dependent on the IP factor which could be due to different antibody quality and prevalence of histone modification or binding events.
