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In the older age group, the prevalence of defects was only 5.3% (2 of 38).
These results are consistent with previous observations of faster folding into thin and highly curved membranes, which also contain a higher prevalence of defects.
The prevalence of defects in the subjects from the ABR zones was 42% (15 of 36) and that from non-ABR zone was 26% (10 of 39; Table 2).
The prevalence of defects in this age group was 42% (15 of 36) in zone ABR subjects and 26% (10 of 39) in zone non-ABR subjects, correlating with serum TCDD levels (p = 0.016).
In our cohort, we observed a higher prevalence of defects in children exposed to indinavir in the first trimester, however, this difference did not reach significance and did not concern head or neck defects.
The prevalence of defects at birth increased from 34.2/1000 (95 % CI = 31.9-36.5) to 42.8/1000 newborns (95 % CI = 38.0-47.7) after prenatal ultrasound screening was formally implemented.
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Using conditional logistic regression we compared the prevalence of birth defects overall, any cardiac defects, and right ventricular outflow tract obstruction defects in infants exposed to any SSRI and venlafaxine with the prevalence in siblings not exposed to any antidepressants.
Main outcome measure Prevalence of birth defects, including subtypes of cardiac defects.
Once ascertained, tibial (n = 51) and femoral (n = 55) cartilage defects were combined to measure prevalence of tibiofemoral defects.
Although the prevalence of septal defects and right ventricular outflow tract defects was higher in exposed infants, the lack of an association in the sibling controlled analyses points against a teratogenic effect of these drugs.
RRs for all cardiac defects and major cardiac defects for the PCE and TCE areas suggest an approximate doubling in the prevalence of these defects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com