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However, with EFs, the "ranking goodness" before the fractional threshold is not taken into account and their maximum value is strongly dependent on the ratio of active compounds over decoys in the benchmarking dataset (i.e. prevalence of activity) [2, 4, 7].
Dashed gray lines indicate the prevalence of activity and random picking of compounds.
Virtual screening scores that are uninformative about compound activity assign equal activity probabilities to all compounds, P act(Y) = P[ A= 1 | Y] = P[ A= 1] = p, where p is the prevalence of activity in the molecular dataset.
The prevalence of activity of Src family kinases can be seen from both Motif mapping (Motif 1 and 4) and the large number of Src kinase substrates identified.
Prevalence of activity limitations and participation restrictions was 80.4% and 93.2%, respectively.
The current prevalence of activity limitations related to injuries was 4.4%.
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In a systematic review, the one-year prevalence of activity-limiting NP in the general population was 1.7%-11.5% [ 2] referring to one survey among Hong Kong residents [ 17], and one survey among patients from British general practices [ 18].
6 7 When estimating the global prevalence of activity-limiting LBP using 165 studies from 54 countries, Hoy and colleagues found the mean point and 1 month prevalence to be 11.9±2.0% and 23.2±2.9%, respectively.
However, the percentage of prevalence of activities varied considerably from one pathway to another.
This is the first study to look at the prevalence of activities or events in a seven day window in pregnant women.
A further limitation of this study is that the study population is older than the general population of pregnant women in Australia[ 23], is highly educated and speaks English impacting the generalisability of the results, especially for prevalence of activities that differ with maternal age, education or socioeconomic status.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com