Sentence examples for prevalence of activation from inspiring English sources

Therefore, a prevalence of activation should render T-cells responsive to antigens, whereas a prevalence of inhibition should lead to T-cell anergy.

As to the PKC and JNK pathways, their role and prevalence of activation remain poorly known in human hepatocarcinogenesis, although some studies have underlined their potentially oncogenic properties (Delpuech et al, 2002; Guo et al, 2005; Wu et al, 2008).

23 Accordingly, more therapeutic interest has been paid to the STAT3-activating cytokines, due to the prevalence of STAT3 activation in diverse human cancer types.

The macrophage anti-inflammatory response to IL-13 seems to be predetermined by the prevalence of the activation of STAT3 and STAT6 over STAT1.

The prevalence of the activation of the HGF/c-Met in human malignancies has driven rapid growth in drug development to target this signaling axis for cancer therapy.

In agreement with Oshiro and colleagues [ 1], previous observational studies have shown a high prevalence of fibrinolytic activation after major trauma [ 13, 14], but doubt remains as to the best method of rapid detection.

To assess the prevalence of STAT3 activation in primary feline OSCC samples, a tissue microarray was constructed from 37 archived feline OSCC surgical biopsies and immunohistochemical staining for pSTAT3 was performed.

To assess the prevalence of STAT3 activation in primary feline OSCC samples, a tissue microarray (TMA) was made from archived feline OSCC surgical biopsies and immunohistochemistry for pSTAT3 was performed.

Given the prevalence of UPR activation in AD and related dementias, our data provide an increasingly compelling argument for the development neuroprotective therapies aimed at restoring neuronal protein synthesis rates, at least in part [ 11], and reducing phosphorylation of tau, for treatment of these diseases.

The ERK2 protein was found as the most frequently phosphorylated protein in these GC cell lines (see online supplementary figure S6E), which is consistent with a previous report about the high prevalence of ERK activation in GC. 5 Although 6497 phosphorylation sites were detected in the proteome, no phosphorylation of synbindin was identified in any cell line.

With the prevalence of excessive Stat3 activation in lungs of IPF patients and the capability of therapeutically targeting components of the gp130 signalling cascade, our findings are likely to be of clinical relevance.