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Despite the varying degrees of disease prevalence, grade 1 hypertension in general should receive more attention in primary care particularly among those untreated patients, as most ischemic strokes could occur at this stage [ 32].
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The prevalence of Grade 3 or Grade 4 thrombocytopenia at the nadir prior to baseline or dose escalation of the RNA fragments was 43% (20/46 treatment cycles) and 4.3% (2/46) respectively (Table 2).
Because of the low prevalence of grade 3 JSN in this sample, we combined grades 2 and 3 for analyses.
Across age subgroups, the prevalence of grade 3/4 DRAEs tended to decrease over the course of therapy, with a concurrent trend for increasing prevalence of grade 1/2 DRAEs, suggesting a shift to less-severe toxicity with continued sorafenib treatment.
Importantly, the prevalence of grade 3 diarrhoea was low throughout, and there were no instances of grade 4 diarrhoea.
The prevalence of grade 1 malnourishment was 46.2 %.
Cancer-related fatigue, as defined according to ICD-10 criteria, was reported in 12% to 21% of patients, and prospective clinical trials showed a prevalence of Grade 3/4 fatigue according to Common Toxicity Criteria of 0% to 18%.
The prevalence within grade 7 was >70% confirming the high prevalence in this area.
The prevalence of grade 2 disability (visible) was found to be 10.1%.
Reported asthma prevalence by grade ranged from 7.7 to 10.3 % (Table 2).
Fowler et al. reported that asthmatic children had a higher prevalence of grade failure, learning disabilities, and absenteeism [ 10].
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