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According to Martin et al. [ 4], this value is called design prevalence, and it describes the prevalence assumption for which the sensitivity estimate of the SSC is valid.
We considered this latter figure to be a more realistic estimate of the prevalence of CD and, therefore, adopted this figure for our base case prevalence assumption; 23,037 patients were used as the upper limit of the range (Ipsen Biopharm Ltd ,unpublished data, October 2012).
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Sheron et al. [ 17] modelled the STL under a range of prevalence assumptions.
This would allow the prevalence data, assumptions about survival and data from incidence assays to join forces to produce better estimates.
DisMod's uses the same observed health administrative data, but models prevalence using the assumption of a stationary population.
The analyses were repeated including secondary care data to derive combined primary and secondary care consultation prevalence, on the assumption that some patients may be diagnosed or only consult in secondary care as is particularly likely in Sweden.
Based on the calculated prevalence and the assumption of a 4 month treatment period, panitumumab is modeled to provide savings of 7.67 million euro/year to the Italian healthcare system compared with cetuximab.
More complex mathematical relationships exist between incidence and prevalence when those assumptions cannot be met.
Assumptions: Prevalence of generalized chronic back pain of 10%.
The sample size was calculated using single population proportion formula with the following assumptions; prevalence of substances use 17.5%, which was obtained from research conducted among college students in North West Ethiopia [ 12].
The sample size was calculated using the following assumptions: prevalence of TB in rural community of 0.36% [ 6], 95% CI, margin of error of 20% and non-response rate of 10%.
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