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The higher cost-effectiveness ratio of 20,086 USD/QALY measured in the second stratum (7< HbA1c <8.5 [53 69 mmol/mol]) was below prevailing thresholds used to decide whether or not an intervention is cost-effective (e.g., 50,000 USD for the U.S). (35).
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At the prevailing threshold of €20,000/QALY the probability for PREP being cost-effective compared to UC was 83%.
When focusing on quality adjusted survival, PREP has an 83% probability of being cost-effective at the prevailing threshold of €20,000/QALY.
In conclusion, it would appear that the balance of evidence suggests that DMDs for patients with MS are not cost-effective when measured against prevailing cost/QALY thresholds.
Therefore, the conclusion from the study was that given prevailing ICER thresholds, perindopril is very likely to be cost effective.
Savings might be offset by providers not incentivized by the contract and, under prevailing (statistical) minimum savings thresholds, the efforts required to gain from participating in the program may be large.
Moreover, the majority of sensitivity analyses produced ICERs that are well below the prevailing willingness to pay threshold for an additional QALY (range from dominance till €45,906/QALY).
First, they suggest that as worm breakpoints are dependent upon the prevailing vector biting intensity, setting such thresholds for chemotherapy-based intervention programmes should take account of this factor.
Secondly, the acclimatisation approach HeRATE adjusts the initial thermal thresholds automatically to the prevailing local climate.
Figures 2c and 2d show the combined effects of fold change and spot intensity or cycle threshold and illustrate the prevailing impact of fold change on data correlation.
To what extent PRCV spread because it could overcome prevailing immunity (as assumed by the invasion threshold model) or because it had other advantages, is not clear.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com