NPHS2 mutations lead to dysfunction of the glomerular filtration barrier with the prevailing renal pathology being focal segmental glomerulosclerosis (FSGS) [ 3, 9, 11].
This further supports the concept that macroangiopathy, rather than microangiopathy, is the prevailing renal pathology underlying nonalbuminuric CKD (17), which nowadays is the predominant form of renal impairment in subjects with type 2 diabetes (17, 22– 22).
Until quite recently, the prevailing view regarding the biology and pathology of astrocytes among those studying clinical disorders and structural lesions of the central nervous system (CNS) was most likely to be that (1) astrocytes are supportive glial cell components in neural tissue and (2) reactive astrogliosis is a reliable and sensitive marker of diseased tissue.
The specimens obtained for histology will be stored for 30 years, according to prevailing guidelines from the Dutch society for pathology [ 22].
While the prevailing view holds Th17 cells responsible for pathology in most inflammatory diseases, recent data also support a tissue-protective function of IL-17 in models of graft versus host disease, colitis, and bronchial hyperreactivity [ 2].
The prevailing hypothesis for the genetic causes underlying DS pathology is that individual phenotypes are caused by an extra copy of one or more of the ∼310 genes present on Hsa21 (Ensembl release 62, including known and newly identified protein-coding and RNA genes but excluding pseudogenes; http://www.ensembl.org/Homo_sapiens/Location/Chromosome?r=21 1-48129895).
At present, the prevailing hypothesis is that MDSCs represent a pathologic, functional state of myeloid cells normally found in healthy individuals (i.e., granulocytes and monocytes) summoned by chronic inflammatory pathologies.
Still, the currently prevailing concept postulates an origin within the transentorhinal cortex from where pathology spreads throughout the cortex [ 1].
In AD and other tauopathies, MAPT is hyperphosphorylated, which has led to the prevailing hypothesis that increased phosphorylation of MAPT is the root cause of pathology, causing decreased binding of MAPT to microtubules, which leads to destabilized microtubule networks and ensuing trafficking deficits within diseased neurons.
The prevailing Empire stories celebrate the individualism, violence and greed that express the pathologies of our collective human immaturity, while denying the potentials for community, love, and nurturing service that define our more mature human nature.
