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This may also suggest that TSC1 has a separable function at cytoplasmic foci that is independent of TSC2 and independent of negative regulation of mTOR by TSC1/TSC2.
The formula in Eq. (3) is a separable nonlinear least squares problem 2– 4 where the model is given by a linear combination of nonlinear functions.
IL-36 signaling has been presumed to function analogously to IL-1.
Based on mutant phenotype, TKL1 is presumed to contribute to the supply of AAAs; the function of the ScTKL2 isogene presumed complementary of TKL1 remains unclear.
Suppose X to be separable.
These results suggest that there are two separable functions in the non-catalytic domain of ARFGAP1, binding to Golgi membranes and interacting with the actin cytoskeleton.
It is a nonlinear multimodal and separable function with a large number of local minima.
However, the applicability of this method is restricted by assumptions requiring the kernel and objective functions to be continuous and differentiable, as well as the dataset being separable.
Ascl1 is known to be required for neuronal-subtype specification, which is separable from its better-known proneural function (Goridis and Brunet, 1999).
Identifying the molecular mechanisms by which c-Myc contributes to the separable functions of tumor induction versus maintenance will be of great interest in the future.
This further lends support to the idea that the acetylation and deubiquitination modules of SAGA are separable in function.
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