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Since most genetic variation lies in nonprotein-coding regions of the genome whose presumed function is entirely regulatory, understanding gene regulation in a cell type and developmental state-specific manner will be important to connect human genetic variation to disease mechanisms.
The constitutive expression of HpCuMT and the exclusive preference of this isoform for Cu+ support this presumed function.
This presumed function of RNA Pol II, which would be compromised by the rpb2-m203 mayalson, may also be affected by mutation in the Med8-Med18-Med20 submodule.
Metabolic reactions are divided into groups called metabolic pathways, which are typically constructed heuristically according to their connectivity and presumed function [ 1].
Although detection of a gene with a presumed function does not definitely prove its activity, the association of its presence with complementary nutritional and biochemical data supports the conclusion that it functions as predicted.
Based on the similarities in position, cellular composition, connections to the nervous system, and presumed function, we suggest that the circumoral ring of mechanoreceptors in appendicularians is homologous to the coronal organs of other tunicates.
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We show the HMMerThread domains graphically in direct relation to conserved domains from InterProScan [41], which gives the user an immediate overview of the presumed functions of the protein under study.
The secreted protein-encoding genes fell into a few groups: 31 genes encoded proteins with presumed functions as catalytic enzymes and 113 genes encoded peptides that had less than 220 amino acids, including the processed signal peptide.
They were chosen to be located on different chromosomes (with the exception of RARB2 and RASSF1A), and to represent a wide range of established or presumed functions.
Compared to the hypothesis-driven linkage and candidate-gene studies, GWAS is unbiased with regard to presumed functions or locations of causal variants.
This finding is especially interesting when considered in concert with the profiles of the other levels of methylation of H3K27 and their presumed functions.
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