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YouTube's presumed disruption of traditional television hasn't happened as quickly as people thought it would.
Conversely, the R33Q mutant, which we previously found to be better phosphorylated than wild-type Parkin [ 26] due to presumed disruption of the Ubl domain autoinhibition, showed only a moderate change in phosphorylation by PINK1 upon addition of ubiquitinPhospho-Ser65 (Fig EV 4).
Analysis of cultured Kc167 cells showed a similar pattern to that of early embryos, with no discernable difference in pairing of a euchromatic locus among G1, S, and G2 subpopulations, but a presumed disruption during later stages of M phase (Williams et al. 2007).
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This has been explained by a presumed selection against the disruption of gene expression by transposable elements[ 10].
Seeking POF genes has to date largely focused on coding variants, presuming plausible protein disruption.
It is presumed that dysregulated astrocyte hemichannel activity leads to the disruption of homoeostatic ion and neurotransmitter gradients (i.e. K+ and glutamate respectively) via the bi-directional trafficking of molecules through open hemichannels (Giaume et al., 2010).
The PT rates are significantly impacted by both mutational disruptions to internal hydrogen bond networks and the presumed structural rigidity of β-strand 7 as probed by circular permutation.
The disruption of VHL that frequently occurs in clear cell RCC is therefore presumed to play an important role in the upregulation of PTHLH 16– 16.
DWI has been suggested as a useful tool in differentiating these aetiologies from acute optic neuritis (presumed autoimmune aetiology) [76, 77], where there is increased diffusivity in demyelinating plaques, related to disruption of myelinated axons, and decreased fractional anisotropy.
The mechanisms between voluntary turnover and the ultimate financial performance of the organization are presumed to be workforce-related, viz., lower productivity and customer satisfaction as well as higher disruption, accidents and errors.
This may be associated with the disruption at the ends of the crystal domains of the fibrils, which are presumed to be accessible to water and hence may be plasticised or undergo hydrolytic attack.
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