Due to these presumed alterations in intestinal physiology induced by PPI and/or NSAID use, we postulate that PPIs and NSAIDs may play an etiological role in the development of IBS.
Genomic alterations in the PI3K pathway were identified in three of the patients' cancers, demonstrating that these presumed activating alterations do not preclude prolonged benefit from capecitabine.
Chemical alteration of an ingredient is presumed to alter its biologic behavior and hence a separate safety assessment is required to establish reasonable expectation of safety or that the altered ingredient is comparable to the native ingredient in relevant characteristics.
Changes in the intrinsic activity of resting-state networks are presumed to represent alterations in functional brain connectivity and may mark neurodegeneration in an early, presymptomatic stage.
These results are suggestive that weak regulation of protein synthesis, where the presumed focus is proteome alteration, appears to contribute to the morphogenetic switch from vegetative to filamentous growth in response to alcohols.
It is presumed that other genetic alterations are required to initiate invasive UCC.
Such alterations are presumed to represent the second hit, according to Knudson's two-hit hypothesis (OMIM #167000) [ 3].
In addition, several interruptions of the reading frame and placements of several indels were adjusted (see additional file 1), amounting to 34 alterations in presumed sequence homology.
Pathogenetically, SVD-related chronic hypoperfusion of the white matter and BBB alterations are presumed to lead to the degeneration of axons and myelin sheets, i.e. to WMLs [ 59, 98, 101, 136, 137, 140].
