Exact(15)
However, in in vivo models, endogenous concentration of β-lyase is sufficient for activation of these selenium molecules to its presumed active moiety, methyl selenol.
A 10 ns molecular dynamics simulation confirmed the docking results of both stability of the 1XMU-ligand complex and the presumed active conformation.
To further expand the chemical series of indoline-based GPR119 agonists, several heterocyclic core systems were introduced as surrogates of the carbamate spacer that mimic the presumed active conformation.
Our results provide evidence that increased serotonergic fibers density caudal to the lesion in Ngn2-hENPs transplanted rat is associated with a presumed "active" distribution of 5HT1A receptors.
There was progression of presumed active anaplastic germ cell tumour in 8 patients.
CG30461 appears to terminate immediately prior to the presumed active site of the enzyme (HEXXH, Figure S5).
Similar(45)
Researchers at several institutions are developing tests that will reveal the presence of these enzymes and, they presume, active periodontal disease.
In individuals whose genotype encodes an apparently less functionally active form of CFH (e.g. 402H homozygotes), the effect of raising the concentration of the presumed more active form (402Y) may, however, be greater than in the general population.
It is presumed that active x2 can only be created by x1 that is bound to the scaffold, and that x1 bound to scaffold cannot create active y2.
Against the similar catalytic domain of GHF5 endoglucanase (EXPDB No: 1TVP_A) from Pseudoalteromonas haloplanktis, it was presumed that active amino acids of Tth Man5 β-mannosidase were Glu141 and Glu238 [ 16].
If drug clearance can be demonstrated in such a model, clinical trials may not be necessary (presuming no active metabolites).
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