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The VDR is a high-frequency, time-cycled pressure ventilator that can ventilate, oxygenate and promote secretion removal.
Briefly, the heart and lungs were surgically exposed and the lungs were ventilated with a volume cycled, positive pressure ventilator (Flexivent, Scireq, Montreal, Que., Canada) with different ventilation strategies as described in detail under the experimental design section.
The trachea was cannulated and animals were ventilated with room air using a positive pressure ventilator (Harvard Rodent Ventilator).
The neck was opened with a ventral midline incision, and a tracheostomy was performed and the rats were ventilated with room air from a positive pressure ventilator (Inco, India) using compressed air at a rate of 70 strokes/min and a tidal volume of 10 ml/kg.
Regardless of the type of their previous ventilatory support (synchronised intermittent mandatory ventilation, spontaneous breathing with T-piece, or intermittent positive pressure ventilator) all patients were sedated with propofol (2 mg/kg) and fentanyl (4 μg/kg) and muscle was relaxed with cis-atracurium (0.2 mg/kg).
CI, confidence interval; CV, conventional ventilation; HFOV, High-frequency oscillation ventilation; SD, standard deviation; VDR, volume diffusive respirator (high-frequency time-cycled pressure ventilator); WMD, weight mean difference.
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In a teleconference yesterday, Dr. Bradley Perkins, an anthrax expert at the centers, attributed the outcomes to aggressive treatments with antibiotics, drugs to maintain blood pressure, ventilators to aid breathing, and draining fluid that accumulates in the chest, compressing patients' lungs.
Taking into account the requirements of the NHI care program for PMV patients, we added two more criteria for selecting study patients: (1) use of invasive ventilators or negative pressure ventilators at the initiating stage of care, and (2) > = 17 years of age on the 21st day of MV.
Rats were ventilated with a peak-pressure ventilator, with initial tidal volume set at 1 ml/100 g and adjusted as needed, on the basis of arterial blood gas levels.
After World War II he improved this into the Blease 'Pulmoflator', which was the first British positive-pressure ventilator in commercial production.
Historically, a noninvasive, negative-pressure ventilator, more commonly called an iron lung, was used to artificially maintain respiration during an acute polio infection until a person could breathe independently (generally about one to two weeks).
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