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"He can speak with senior executives and then with subsea engineers, and ask probing questions about pressure variants and burst steel casing.
Because these loci are unlikely to have been under selective pressure, variants altering drug metabolism have in some cases increased to reasonable frequency and can be associated with large effects [14].
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After several rounds of selection with increasing levels of inhibition pressure, gene variants coding for polymerases with improved tolerance to plant inhibitors were exponentially enriched over variants with no advantage.
Selective pressure against variants in the proximal promoter region, which could potentially result in altered expression levels, may be low.
We speculate that the biological importance of this gene has resulted in negative selective pressure against variants that alter TDP-43 amino-acid sequence.
In laboratory conditions, evolutionary engineering is usually a phenomenon of long term adaptation of cells under selective pressure, where variants of cell population with a selective advantage exponentially take over the initially dominating cells [ 16].
Although position 16 is part of the well-studied HLA-B*57-restricted CTL epitope ISW9 [ 9] and hence target of selective pressure, escape variants have only been described for positions 14 and 15 [ 10, 11].
Common variants available in clinical practice include systolic pressure variation, pulse pressure variation, stroke volume variation, and the Pleth Variability Index.
Also, it is possible that multiple in vivo microenvironments, or a variable host immune response, exert dynamic selective pressures on variants within the population to maintain genome diversity in the in vivo population.
To investigate the associations between the non intraocular pressure (IOP related genetic variants (genetic variants associated with vulnerability of the optic nerve independent of IOP) and primary open-angle glaucoma (POAG), including normal-tension glaucoma (NTG) and high-tension glaucoma (HTG), and between the non-IOP-related genetic variants and a family history of glaucoma.
Another possibility is that common genetic variation in ovine SPRN driven by an unstable DNA tract will apply selection pressure for PrP variants with altered physiological activity to offset the action of the SPRN variants.
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CEO of Professional Science Editing for Scientists @ prosciediting.com