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The large proportion of NeuAcα2-6 may exert selective pressure for selection of influenza variants with altered receptor preference for this human-type α2-6 receptor, a crucial first step for generating a human pandemic.
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The same is true for the mutation rate MR (Supplementary Table S4), the selection pressure for parent selection SP (Supplementary Table S5) and the success ratio SR that determines how many children have to outperform at least one of their parents (Supplementary Table S6).
In particular, the developmental environment is important, because selection pressure for survival is highest during development.
Australian involvement in World War II led to increasing pressure for the selection of the Australian Blue Ensign over the Union Jack as a national flag.
The high antibiotic consumption for the treatment of AOM represents the major pressure for resistance selection [ 24].
Pressure for the selection of azole-resistant species has been reported by several authors [ 28], resulting in the introduction of recommendations for good use of antifungal drugs [ 18].
With the widespread use of artemisinin treatment, resulting in continued pressure for natural selection of the most resistant parasites, resistance may emerge in regions beyond Asia, including Africa.
The high antibiotic consumption for the treatment of AOM (the most common infection for which antibiotics are prescribed in children in the community [ 2]) represents the major pressure for resistance selection [ 11].
To test whether the phylogenetic information was biased by selection pressure, neutrality tests for selection (Tajima's D and Fu's F test) were performed using DNAsp, version 4.20.2 [33] [35].
Pressures for such selection out may be illness related or administrative.
One of the evolutionary pressures for the selection of PurN instead of PurT in eukaryotic organisms could be associated with the emergence of the mitochondrial respiratory chain.
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