11.One objective of hemodynamic treatment during esophageal/gastric varices rupture should be to restore a satisfactory mean blood pressure to preserve tissue perfusion (strong agreement).
In the phase of early resuscitation after a severe burn, it is of paramount importance to promptly restore vascular volume and to preserve tissue perfusion but minimize tissue edema [ 16].
The biologic goal of transfusion therapy is to preserve tissue perfusion in order to minimize the damage – both physiologic and structural – that results from prolonged or repeated episodes of ischemia [ 1, 2].
To study cellular interactions, preserving tissue structure is necessary.
Preserved tissue was placed in long-term storage at −80°C.
In this intricate system, activated protein C plays a key role in preserving and restoring tissue perfusion through its potent antithrombotic, profibrinolytic, and anti-inflammatory properties [ 6- 8].
Although the authors did not design the study to assess potential mechanistic explanations for their promising results, diaphragmatic function was likely preserved due to improved tissue perfusion and decreased pro-inflammatory responses.
It is possible that the differential effect of low achieved BP on the brain compared with the heart originates from a more effective cerebral autoregulation, i.e., a better ability to preserve blood flow and tissue perfusion when BP is markedly reduced by treatment, a feature that the brain may share with the kidney.
In current practice, mean maximum PaCO2 and pH associated with permissive hypercapnia are around 8.9 kPa and 7.2, respectively [ 2], and are reported to be well tolerated as long as tissue perfusion and oxygenation are preserved and there are no contraindications [ 5- 7].
The ultimate goals of therapy for shock are to restore effective tissue perfusion, to normalize cellular metabolism, and to preserve and restore tissue function.
