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These studies demonstrate the potential of the bidirectional TSTA system to achieve high levels of gene expression from a weak promoter, while preserving specificity and the ability to image expression of the TG noninvasively.
This may improve sensitivity in family data [29], and allow the combination of family and case-control data, while preserving specificity, where instead of fitting a logistic model for the best MDR or MDR-PDT model, a GEE model is fit and permutation tested.
22 The Panel accepted these MAGNIMS DIS Criteria, which can simplify the diagnostic process for MS while preserving specificity and improving sensitivity (Table 1).
This extension to gapped alignments allows the detection of target sites with varying lengths whilst preserving specificity and consistency, both of which are key features of the original BM approach.
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In this study we show that it is possible to evolve the functionality of binders based on this scaffold as exemplified by one such module, XG-34 specific for non-fucosylated xyloglucan [ 14] while preserving its specificity for xyloglucan.
Thus, the development of an EEG measure that is more sensitive than IEDs, whilst preserving high specificity, would be highly valuable in diagnosis and treatment of epilepsy.
In the third scenario, with 50% prevalence and with 20% of the records missing mother's name, clerical review increased sensitivity to over 96%, while preserving 100% specificity.
In both cases, we created algorithms based on the previous questions to achieve the best possible sensitivity, while preserving reasonable specificity and positive predictive value (PPV).
This strategy builds upon existing methods based on identification of kinase consensus motifs (Linding et al., 2008; Obata et al., 2000; Obenauer et al., 2003) or chemical-genetic approaches (Blethrow et al., 2008; Chi et al., 2008) while overcoming problems associated with consensus motif redundancy and preserving the specificity and context of the cellular environment.
Preserved specificity of TLR-dependent signaling in RAGE −/−, TLR4 −/−, and MyD88 −/− fibroblasts was confirmed by regular activation patterns induced by the MyD88-dependent TLR4 and TLR1/2 agonists LPS-EB and Pam3, respectively, as well as MyD88-independent TLR3 ligand Poly I C (Fig 5E).
This approach must therefore be conducted in both directions: radiologists and nuclear medicine physicians should both know how to correlate PET and CT images, while preserving the specificities of each discipline.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com