Sentence examples for preserving regulation from inspiring English sources

However, it is of interest that the tumour-associated mutations that map to helix αK12 enhance kinase activity and render PI3K insensitive to regulation by Ras, whereas preserving regulation by p85α (Ikenoue et al, 2005; Isakoff et al, 2005; Kang et al, 2005; Samuels et al, 2005; Zhao et al, 2005; Bader et al, 2006; Gymnopoulos et al, 2007; Zhao and Vogt, 2008).

These agents act via a mechanism that modulates the Ca2+-sensitivity of troponin; such a mode of action is therapeutically desirable because intracellular Ca2+ concentration is not perturbed, preserving the regulation of other Ca2+-based signaling pathways.

In return for preserving self-regulation, a number of editors quietly concede there might be fewer of their number, if any, on an oversight body.

Restoring endogenous regulation of vasomotor tone would be desirable to preserve regional regulation of perfusion.

Activations and inhibitions are similarily consistent, if adjusted to background distributions of both regulation types, and stronger signals are properly weighted in order to preserve the regulation kinetics.

In Caco-2 cells with the KRAS G12D, KRAS overexpression preserved the regulation effect of CIP2A in KRAS and abrogated the impact of CIP2A regulation on pERK/ERK and cell proliferation.

This result suggests that, at least in these species, positive selection might act to preserve antisense regulation.

Epitope-tagged TFEB, when expressed at low levels in HeLa cells, preserved its regulation by mTORC1; it was enriched in the nuclei of TSC2-depleted cells and the levels were decreased by rapamycin.

DNA fragments produced by double strand breaks are then left to non-specific processes that rejoin them without regard for preserving normal gene regulation or function, so rearrangements of DNA segments are more likely.

But he is under pressure to support a newspaper industry proposal that would preserve self-regulation and rely on legally enforceable contracts to bind publishers to the system, including the possibility of fines.

Mr. Bragman scoffed publicly at his downstate colleagues' tooth-and-nail battle to preserve rent regulations in 1997, and is seen by liberals as insufficiently committed to abortion rights.