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The success in this area has been due largely to state-dependent and use-dependent characteristics of the drug channel interaction such that the inhibitory effect is most pronounced at partially depolarized membrane potential, thus preserving normal function.
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Therefore, it became possible to preserve normal function of cranial nerves, including facial nerve and hearing preservation, whilst causing minimal injury to the cerebellum and brainstem.
Despite the major discoveries made in the past decade, there are still major gaps in our knowledge as to how miRNAs are involved in preserving normal cardiovascular function and how dysregulation in their expression or biological function results in CVD.
AKI was observed in the vast majority of HH patients with only 19%% preserving normal renal function.
An 85-year-old man, preserving normal cognitive function, complained of progressive dyspnea and visited a local hospital, where he was diagnosed with laryngeal cancer and scheduled for a total laryngectomy.
Maintenance of the fidelity of genetic material is critical for preserving normal cell function and preventing tumorigenesis of normal cells.
It has also been shown that ERT may be effective in preserving normal renal function in children [ 27].
Eliminating seizures while preserving normal brain function will require ever more precise identification of the region or regions responsible for seizures and their relationship with eloquent systems.
Collectively, such evidence indicates therapeutic potential for a MedDiet intervention to assist in protecting and preserving normal cognitive function in older age through slowing down the progression of cognitive decline and reducing risk of developing neurodegenerative pathologies [ 7].
that will identify the presence of AD pathology with high sensitivity and specificity, especially in the preclinical and very early disease stages so new treatments will have the best chance of preserving normal brain function.
The next important step is to understand if and how stimulation of insulin signaling in the brain might facilitate neuroprotection, thereby preserving normal brain functioning.
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