Exact(4)
The drug, called drisapersen, was no better than placebo in preserving muscle function of boys with Duchenne muscular dystrophy.
Taken together, studies in Drosophila and mammals indicate an important role of protein quality control in preserving muscle function during aging and preventing age-related myopathies in humans.
Studies in Drosophila have already pinpointed key cellular age-related changes in muscle and the role of stress resistance pathways in preserving muscle function during aging.
Our findings may inform preventive efforts targeted at potentially preserving muscle function in older persons and, ultimately, can facilitate strategies to reduce the burden of disability for persons with diabetes.
Similar(56)
By incorporating a small muscle mass, and therefore inducing a larger reduction in muscle K+ than commonly observed during whole-body exercise [72], the authors hypothesised that NaHCO3 would attenuate the augmented K+ efflux from the small muscle mass and therefore better preserve muscle function [65].
The latter could be important to preserve muscle function.
Future studies should explore if better glycemic control can preserve muscle function in diabetes.
There are also some studies that indicate manipulation of ROS activities can preserve muscle function during aging (5, 51).
Such increase in α2 mRNA expression at fatigue may be a compensatory response to preserve muscle function.
Altogether these results suggested that E2f1 deletion preserves muscle function in the mdx model of Duchenne dystrophy.
Patients are currently being recruited for a study to determine whether IGF-1 therapy improves or preserves muscle function in DMD (see http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01207908).
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