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We suggest that resveratrol influences bone metabolism possibly representing a primary anabolic modality in preserving bone integrity.
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Cell cell communication between cells of the osteoclastic lineage and cells of the osteoblastic lineage is thought to couple resorption and formation so as to preserve bone integrity and achieve homeostatic bone renewal.
In addition, the delay in disease recurrence observed in the trials of zoledronic acid supports the potential for anticancer benefits from a therapy designed to preserve bone integrity [ 44- 46].
One of the greatest therapeutic challenges in the chronic kidney disease population is the management of bone and mineral metabolic parameters in order to preserve bone integrity, minimize cardiovascular calcification, and manage serum levels of parathyroid hormone (PTH), calcium and phosphorus.
The results provide a molecular framework for understanding the role of severe hypoxia in preserving bone marrow progenitor cell integrity and perhaps insights into the role of hypoxia in regulating cell biology in hypoxic niche environments such as the endosteum.
In normal bone, homeostasis is maintained and bone integrity is preserved by a continuous cycle of bone renewal.
Na18F PET provides an assessment of bone integrity and turnover.
A balance between bone resorption and bone formation is required for maintaining bone integrity during remodeling.
Mechanical loading plays an essential role in maintaining bone integrity.
Gravity contributes to the maintenance of bone integrity.
Importantly, we discuss risk factors influencing subchondral bone integrity.
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