Therefore, it became possible to preserve normal function of cranial nerves, including facial nerve and hearing preservation, whilst causing minimal injury to the cerebellum and brainstem.
Pharmacologic manipulation of the haematopoietic stem cell niche to preserve normal function is a new paradigm for treating acute myeloid leukemia.
The success in this area has been due largely to state-dependent and use-dependent characteristics of the drug channel interaction such that the inhibitory effect is most pronounced at partially depolarized membrane potential, thus preserving normal function.
It will be interesting to use transgenic approaches to determine whether restoring gene function in the liver of que mutants preserves normal CNS function, as shown in mammals (Strauss et al., 2006; Skvorak et al., 2009a; Skvorak et al., 2009b).
Expression of A20 preserves normal liver function as assessed by prothrombin time.
However, it is unclear whether SIRT3 is activated to regulate protein function in response to metabolic changes or whether SIRT3 constitutively deacetylates proteins to preserve their normal function.
The results presented in this study provide support for the idea that SIRT3 repairs nonenzymatic acetylation lesions on mitochondrial proteins in order to preserve their normal function.
This supports the concept that application of estrogen is beneficial in preserving the normal function of the vascular system [ 33, 34].
The homeostasis of vascular tissue is associated with constant remodeling in order to preserve the normal function of the blood vessels.
Despite the major discoveries made in the past decade, there are still major gaps in our knowledge as to how miRNAs are involved in preserving normal cardiovascular function and how dysregulation in their expression or biological function results in CVD.
We conclude that the homeostatic mechanisms that preserve normal membrane function vary: (1) with the nature of the stress that perturbs fluidity, (2) with local conditions within each tissue, and (3) possibly with the thermal tolerance of individual species.
