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Our current objective was to determine whether pharmacologic enhancement of insulin sensitivity and myocardial glucose uptake preserves cardiac function and survival in the setting of primary heart failure.
To circumvent some of these limitations and to optimize retention and survival of transplanted cells acutely post-MI, we tested fibrin polymer that is a biodegradable structural matrix important in wound healing, improves transplanted cell survival, induces angiogenesis, reduces infarct expansion, and preserves cardiac function after a myocardial infarction [7] [9].
Recent animal experimental studies suggested that metformin treatment reduces myocardial injury and preserves cardiac function in non-diabetic rats after experimental myocardial infarction.
We have recently demonstrated that apelin protects rat heart against I/R injury, prevents cardiac ROS-dependent hypertrophy and preserves cardiac function in cardiac remodelling (Foussal et al., 2010; Pisarenko et al., 2010).
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Other companies have developed potential vaccines against staphylococcus infections and drugs to preserve cardiac function after a heart attack.
Melatonin treatment preserved cardiac function and reduced oxidative damage and apoptosis.
de Groot PC, van Dijk A, Dijk E, Hopman MT. Preserved cardiac function after chronic spinal cord injury.
On the other hand, oral supplementation with l-hArg in mice improved neurological deficits and preserved cardiac function in experimental models of stroke and heart failure, respectively.
In preclinical testing, ventricular wall injection of hydrogels has been shown to be effective in modulating ventricular remodeling and preserving cardiac function.
This study showed that melatonin ameliorated diabetic MI/R injury by modulating Nrf-2-HO-1 and MAPK signaling, thus reducing myocardial apoptosis and oxidative stress and preserving cardiac function.
JNK1 is required to preserve cardiac function in the early response to pressure overload.
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CEO of Professional Science Editing for Scientists @ prosciediting.com