With the other solution, each sub-histogram was smoothed by changing the corresponding original probability density function with the brightness preserving weight clustering histogram equalization (BPWCHE) [11].
Here, we used 100 random networks while preserving weight, strength, and degree distribution of the original network.
In the simplest formulation of LLE, the method will preserve weights for each data point to the surrounding K nearest neighbours per data point, as measured by Euclidean distance from a point of interest.
Upon comparison of DMF treated R6/2 mice with controls treated with carrier solution alone, there was a trend to preserved body weight after DMF treatment with a significant preservation of body weight on days 85 and 90 of life (Fig. 2A).
In addition to the anticachectic effect, imidapril also produced a stabilising effect on the growth of the MAC16 tumour, which complicates the interpretation of the data on preserving body weight, since weight loss in animals bearing the MAC16 tumour is directly proportional to tumour mass (Beck and Tisdale, 1987).
Clinically, however, the MCP mice had reduced severity of disease: they had preserved body weight (mean 23.6 g), which is similar to sham controls (Figure 4, Table 1), whilst kidney weights (0.16 g) were higher than shams but significantly reduced compared to those exposed to FA but maintained on water alone (Figure 4, Table 1).
Blackburn also demonstrated that lean body mass can be preserved during weight loss with carefully designed very low calorie treatments which became known as the protein sparing modified fast (PSMF).
In summary, DMF treatment leads to a preserved body weight and prolonged survival in R6/2 mice.
This second explanation is supported by the fact MCP mice have preserved body weight and their kidneys did not exhibit such acute gross swelling as those exposed to FA but maintained on water alone.
SkQ1 preserved total weight and volume of the organ, the volume of thymic cortex and medulla, the thymic cellularity, and the number of CD3+, CD4+, and CD8+ cells in the thymus.
